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Talin and kindlin: the one-two punch in integrin activation

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 6-16 doi: 10.1007/s11684-014-0317-3

摘要：

Proper cell-cell and cell-matrix contacts mediated by integrin adhesion receptors are important for development, immune response, hemostasis and wound healing. Integrins pass trans-membrane signals bidirectionally through their regulated affinities for extracellular ligands and intracellular signaling molecules. Such bidirectional signaling by integrins is enabled by the conformational changes that are often linked among extracellular, transmembrane and cytoplasmic domains. Here, we review how talin-integrin and kindlin-integrin interactions, in cooperation with talin-lipid and kindlin-lipid interactions, regulate integrin affinities and how the progress in these areas helps us understand integrin-related diseases.

关键词： signal transduction     transmembrane domain     nanodisc     integrin     talin     kindling     cell adhesion    

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Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

《结构与土木工程前沿（英文）》 2009年 第3卷 第2期   页码 173-179 doi: 10.1007/s11709-009-0034-1

摘要： Flutter derivatives are essential for flutter analysis of long-span bridges, and they are generally identified from the vibration testing data of a sectional model suspended in a wind tunnel. Making use of the forced vibration testing data of three sectional models, namely, a thin-plate model, a nearly streamlined model, and a bluff-body model, a comparative study was made to identify the flutter derivatives of each model by using a time-domain method and a frequency-domain method. It was shown that all the flutter derivatives of the thin-plate model identified with the frequency-domain method and time-domain method, respectively, agree very well. Moreover, some of the flutter derivatives of each of the other two models identified with the two methods deviate to some extent. More precisely, the frequency-domain method usually results in smooth curves of the flutter derivatives. The formulation of time-domain method makes the identification results of flutter derivatives relatively sensitive to the signal phase lag between vibration state vector and aerodynamic forces and also prone to be disturbed by noise and nonlinearity.

关键词： long-span bridges     wind-induced vibration     flutter derivatives     forced vibration test     time-domain method     frequency-domain method    

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Transmembrane transport of polycyclic aromatic hydrocarbons by bacteria and functional regulation of

Hongqi Wang, Ruhan Jiang, Dekang Kong, Zili Liu, Xiaoxiong Wu, Jie Xu, Yi Li

《环境科学与工程前沿（英文）》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1188-2

摘要： Explaintheadsorption, uptake and transmembrane transport of PAHs by bacteria. Analyze functional regulation of membrane proteins inthe transmembrane transport. Proteomics technology such as iTRAQ labeling was used to access expressed proteins. Single cell analysis technology wereused to study the morphological structure. In recent years, increasing research has been conducted on transmembrane transport processes and the mechanisms behind the microbial breakdown of polycyclic aromatic hydrocarbons (PAHs), including the role of membrane proteins in transmembrane transport and the mode of transmission. This article explains the adsorption, uptake and transmembrane transport of PAHs by bacteria, the regulation of membrane protein function during the transmembrane transport. There are three different regulation mechanisms for uptake, depending on the state and size of the oil droplets relative to the size of the microbial cells, which are (i) direct adhesion, (ii) emulsification and pseudosolubilization, and (iii) interfacial uptake. Furthermore, two main transmembrane transport modes are introduced, which are (i) active transport and (ii) passive uptake and active efflux mechanism. Meanwhile, introduce the proteomics and single cell analysis technology used to address these areas of research, such as Isobaric tags for relative and absolute quantitation (iTRAQ) technology and Nano Secondary ion mass spectrometry (Nano-SIMS). Additionally, analyze the changes in morphology and structure and the characteristics of microbial cell membranes in the process of transmembrane transport. Finally, recognize the microscopic mechanism of PAHs biodegradation in terms of cell and membrane proteins are of great theoretical and practical significance for understanding the factors that influence the efficient degradation of PAHs contaminants in soil and for remediating the PAHs contamination in this area with biotechnology.

关键词： Polycyclic aromatic hydrocarbons     Transmembrane transport     Adsorption and uptake of hydrocarbons     Proteomics     Functional regulation of membrane protein     Single cell analysis technology    

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Entity and relation extraction with rule-guided dictionary as domain knowledge

《工程管理前沿（英文）》   页码 610-622 doi: 10.1007/s42524-022-0226-0

摘要： Entity and relation extraction is an indispensable part of domain knowledge graph construction, which can serve relevant knowledge needs in a specific domain, such as providing support for product research, sales, risk control, and domain hotspot analysis. The existing entity and relation extraction methods that depend on pretrained models have shown promising performance on open datasets. However, the performance of these methods degrades when they face domain-specific datasets. Entity extraction models treat characters as basic semantic units while ignoring known character dependency in specific domains. Relation extraction is based on the hypothesis that the relations hidden in sentences are unified, thereby neglecting that relations may be diverse in different entity tuples. To address the problems above, this paper first introduced prior knowledge composed of domain dictionaries to enhance characters’ dependence. Second, domain rules were built to eliminate noise in entity relations and promote potential entity relation extraction. Finally, experiments were designed to verify the effectiveness of our proposed methods. Experimental results on two domains, including laser industry and unmanned ship, showed the superiority of our methods. The F1 value on laser industry entity, unmanned ship entity, laser industry relation, and unmanned ship relation datasets is improved by +1%, +6%, +2%, and +1%, respectively. In addition, the extraction accuracy of entity relation triplet reaches 83% and 76% on laser industry entity pair and unmanned ship entity pair datasets, respectively.

关键词： entity extraction     relation extraction     prior knowledge     domain rule    

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Damage identification in connections of moment frames using time domain responses and an optimization

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 851-866 doi: 10.1007/s11709-021-0739-3

摘要： Damage is defined as changes to the material and/or geometric properties of a structural system, comprising changes to the boundary conditions and system connectivity, adversely affecting the system’s performance. Inspecting the elements of structures, particularly critical components, is vital to evaluate the structural lifespan and safety. In this study, an optimization-based method for joint damage identification of moment frames using the time-domain responses is introduced. The beam-to-column connection in a metallic moment frame structure is modeled by a zero-length rotational spring at both ends of the beam element. For each connection, an end-fixity factor is specified, which changes between 0 and 1. Then, the problem of joint damage identification is converted to a standard optimization problem. An objective function is defined using the nodal point accelerations extracted from the damaged structure and an analytical model of the structure in which the nodal accelerations are obtained using the Newmark procedure. The optimization problem is solved by an improved differential evolution algorithm (IDEA) for identifying the location and severity of the damage. To assess the capability of the proposed method, two numerical examples via different damage scenarios are considered. Then, a comparison between the proposed method and the existing damage identification method is provided. The outcomes reveal the high efficiency of the proposed method for finding the severity and location of joint damage considering noise effects.

关键词： damage identification     beam-to-column connection     time-domain response     optimization    

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Controlling microbiological interfacial behaviors of hydrophobic organic compounds by surfactants in biodegradation process

ZHANG Dong,ZHU Lizhong

《环境科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 305-315 doi: 10.1007/s11783-014-0647-z

摘要： Bioremediation of hydrophobic organic compounds (HOCs) contaminated soils involves several physicochemical and microbiological interfacial processes among the soil-water-microorganism interfaces. The participation of surfactants facilitates the mass transport of HOCs in both the physicochemical and microbiological interfaces by reducing the interfacial tension. The effects and underlying mechanisms of surfactants on the physicochemical desorption of soil-sorbed HOCs have been widely studied. This paper reviewed the progress made in understanding the effects of surfactant on microbiological interfacial transport of HOCs and the underlying mechanisms, which is vital for a better understanding and control of the mass transfer of HOCs in the biodegradation process. In summary, surfactants affect the microbiological interfacial behaviors of HOCs during three consecutive processes: the soil solution-microorganism sorption, the transmembrane process, and the intracellular metabolism. Surfactant could promote cell sorption of HOCs depending on the compatibility of surfactant hydrophile hydrophilic balance (HLB) with cell surface properties; while the dose ratio between surfactant and biologic mass (membrane lipids) determined the transmembrane processes. Although surfactants cannot easily directly affect the intracellular enzymatic metabolism of HOCs due to the steric hindrace, the presence of surfactants can indirectly enhanced the metabolism by increasing the substrate concentrations.

关键词： biodegradation     sorption     transmembrane transport     microbiological interfaces     surfactants    

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Terahertz time-domain spectroscopy of high-pressure flames

Jason BASSI, Mark STRINGER, Bob MILES, Yang ZHANG

《能源前沿（英文）》 2009年 第3卷 第2期   页码 123-133 doi: 10.1007/s11708-009-0033-x

摘要： Laser spectroscopy in the visible and near infrared is widely used as a diagnostic tool for combustion devices, but this approach is difficult at high pressures within a sooty flame itself. High soot concentrations render flames opaque to visible light, but they remain transparent to far-infrared or terahertz (THz) radiation. The first far-infrared absorption spectra, to the best of our knowledge, of sooty, non-premixed, ethylene high-pressure flames covering the region of 0.2-2.5 THz is presented. A specially designed high-pressure burner which is optically accessible to THz radiation has been built allowing flame transmission measurements up to pressures of 1.6 MPa. Calculations of the theoretical combustion species absorption spectra in the 0.2-3 THz range have shown that almost all the observable features arise from H O. A few OH (1.84 and 2.51 THz), CH (2.58 THz), and NH (1.77 and 2.95 THz) absorption lines are also observable in principle. A large number of H O absorption lines are observed in the ground vibrational in a laminar non-premixed, sooty flame (ethylene) at pressures up to 1.6 MPa.

关键词： terahertz time-domain spectroscopy     high-pressure flames     H2O absorption lines    

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framework for underground structures in layered ground under inclined P-SV waves using stiffness matrix and domain

《结构与土木工程前沿（英文）》 2023年 第17卷 第1期   页码 10-24 doi: 10.1007/s11709-022-0904-3

摘要： A numerical framework was proposed for the seismic analysis of underground structures in layered ground under inclined P-SV waves. The free-field responses are first obtained using the stiffness matrix method based on plane-wave assumptions. Then, the domain reduction method was employed to reproduce the wavefield in the numerical model of the soil–structure system. The proposed numerical framework was verified by providing comparisons with analytical solutions for cases involving free-field responses of homogeneous ground, layered ground, and pressure-dependent heterogeneous ground, as well as for an example of a soil–structure interaction simulation. Compared with the viscous and viscous-spring boundary methods adopted in previous studies, the proposed framework exhibits the advantage of incorporating oblique incident waves in a nonlinear heterogeneous ground. Numerical results show that SV-waves are more destructive to underground structures than P-waves, and the responses of underground structures are significantly affected by the incident angles.

关键词： underground structures     seismic response     stiffness matrix method     domain reduction method     P-SV waves    

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无监督域自适应的动态参数化学习 Research Article

蒋润华1,2,韩亚洪1,2

《信息与电子工程前沿（英文）》 2023年 第24卷 第11期   页码 1616-1632 doi: 10.1631/FITEE.2200631

摘要： 无监督领域自适应通过学习域不变表示实现神经网络从有标签数据组成的源域到无标签数据组成的目标域迁移。近期研究通过直接匹配这两个域的边缘分布实现这一目标。然而，已有研究大多数忽略域对齐和语义判别学习之间的动态平衡，因此容易受负迁移和异常样本影响。为解决这些问题，引入动态参数化学习框架。首先，通过探索领域级语义知识，提出动态对齐参数自适应地调整域对齐和语义判别学习的优化过程。此外，为获得判别能力强和域不变的表示，提出在源域和目标域上对齐优化过程。本文通过综合实验证明了所提出方法的有效性，并在3个视觉任务的7个数据集上进行广泛比较，证明可行性。

关键词： 无监督领域自适应；优化步骤；跨域判别表示；语义判别    

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针对无监督域自适应问题的深度逐层领域修正算法 Article

Shuang LI, Shi-ji SONG, Cheng WU

《信息与电子工程前沿（英文）》 2018年 第19卷 第1期   页码 91-103 doi: 10.1631/FITEE.1700774

摘要： 为借助深度网络解决领域偏移问题，本文提出逐层领域修正（layer-wise domain correction, LDC）深度域自适应算法。

关键词： 无监督域自适应；最大均值偏差；残差网络；深度学习    

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Frequency domain a9ctive vibration control of a flexible plate based on neural networks

Jinxin LIU, Xuefeng CHEN, Zhengjia HE

《机械工程前沿（英文）》 2013年 第8卷 第2期   页码 109-117 doi: 10.1007/s11465-013-0252-z

摘要：

A neural-network (NN)-based active control system was proposed to reduce the low frequency noise radiation of the simply supported flexible plate. Feedback control system was built, in which neural network controller (NNC) and neural network identifier (NNI) were applied. Multi-frequency control in frequency domain was achieved by simulation through the NN-based control systems. A pre-testing experiment of the control system on a real simply supported plate was conducted. The NN-based control algorithm was shown to perform effectively. These works lay a solid foundation for the active vibration control of mechanical structures.

关键词： active vibration control (AVC)     neural network (NN)     low frequency noise     frequency domain control     multi-frequency control    

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Thermal reffusivity: uncovering phonon behavior, structural defects, and domain size

Yangsu XIE, Bowen ZHU, Jing LIU, Zaoli XU, Xinwei WANG

《能源前沿（英文）》 2018年 第12卷 第1期   页码 143-157 doi: 10.1007/s11708-018-0520-z

摘要： To understand the relation between different nanostructures and thermal properties, a simple yet effective model is in demand for characterizing the underlying phonons and electrons scattering mechanisms. Herein, we make a systematic review on the newly developed thermal reffusivity theory. Like electrical resistivity which has been historically used as a theory for analyzing structural domain size and defect levels of metals, the thermal reffusivity can also uncover phonon behavior, structure defects and domain size of materials. We highlight that this new theory can be used for not only metals, but also nonmetals, even for amorphous materials. From the thermal reffusivity against temperature curves, the Debye temperature of the material and the ideal thermal diffusivity of single perfect crystal can be evaluated. From the residual thermal reffusivity at the 0 K limit, the structural thermal domain (STD) size of crystalline and amorphous materials can be obtained. The difference of white hair and normal black hair from heat conduction perspective is reported for the first time. Loss of melanin results in a worse thermal protection and a larger STD size in the white hair. By reviewing the different variation of thermal reffusivity against decreasing temperature profiles, we conclude that they reflected the structural connection in the materials. Ultimately, the future application of thermal reffusivity theory in studying 2D materials and amorphous materials is discussed.

关键词： thermal reffusivity theory     phonon behavior     structure defects     structural thermal domain (STD) size     2D material     amorphous material    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

《医学前沿（英文）》 2023年 第17卷 第4期   页码 714-728 doi: 10.1007/s11684-022-0959-5

摘要： FRMD6, a member of the 4.1 ezrin–radixin–moesin domain-containing protein family, has been reported to inhibit tumor progression in multiple cancers. Here, we demonstrate the involvement of FRMD6 in lung cancer progression. We find that FRMD6 is overexpressed in lung cancer tissues relative to in normal lung tissues. In addition, the enhanced expression of FRMD6 is associated with poor outcomes in patients with lung squamous cell carcinoma (n = 75, P = 0.0054) and lung adenocarcinoma (n = 94, P = 0.0330). Cell migration and proliferation in vitro and tumor formation in vivo are promoted by FRMD6 but are suppressed by the depletion of FRMD6. Mechanistically, FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of the mTOR signaling pathway. FRMD6 markedly enhances the interaction between mTOR and S6K, subsequently increasing the levels of endogenous pS6K and downstream pS6 in lung cancer cells. Furthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6−/− gene KO MEFs and mice. Altogether, our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway.

关键词： FRMD6     lung cancer     mTOR pathway    

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Analytical method of capsizing probability in the time domain for ships in the random beam seas

LIU Liqin, TANG Yougang, LI Hongxia

《结构与土木工程前沿（英文）》 2007年 第1卷 第3期   页码 361-366 doi: 10.1007/s11709-007-0048-5

摘要： The methods for constructing safe basins of ships and predicting their survival probability in random waves were studied. The nonlinear differential equation of the rolling motion of ships in random beam seas was established considering nonlinear damping, nonlinear restoring moment, and random waves. The random rolling differential equation was solved in the time domain by applying the harmonic acceleration method and by synthetically considering the instantaneous state of ships and the narrowband wave energy spectrum. The numerical simulation of random capsizing course was brought forward, the safe basins were constructed for safe navigation, and the survival probabilities of ships were calculated. As an example, the safe basins on the rolling initial value plane were constructed for a 30.27-meter-long fishing vessel according to different initial conditions and random wave parameters. The survival probabilities of the fishing vessel under different significant wave heights were predicted. Thus, the survival probabilities of ships in random seas can be predicted quantitatively by the proposed method.

关键词： different     survival probability     different significant     nonlinear differential     narrowband    

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Optimum lateral extent of soil domain for dynamic SSI analysis of RC framed buildings on pile foundations

Nishant SHARMA, Kaustubh DASGUPTA, Arindam DEY

《结构与土木工程前沿（英文）》 2020年 第14卷 第1期   页码 62-81 doi: 10.1007/s11709-019-0570-2

摘要： This article describes a novel approach for deciding optimal horizontal extent of soil domain to be used for finite element based numerical dynamic soil structure interaction (SSI) studies. SSI model for a 12 storied building frame, supported on pile foundation-soil system, is developed in the finite element based software framework, OpenSEES. Three different structure-foundation configurations are analyzed under different ground motion characteristics. Lateral extent of soil domain, along with the soil properties, were varied exhaustively for a particular structural configuration. Based on the reduction in the variation of acceleration response at different locations in the SSI system (quantified by normalized root mean square error, ), the optimum lateral extent of the soil domain is prescribed for various structural widths, soil types and peak ground acceleration levels of ground motion. Compared to the past studies, error estimation analysis shows that the relationships prescribed in the present study are credible and more inclusive of the various factors that influence SSI. These relationships can be readily applied for deciding upon the lateral extent of the soil domain for conducting precise SSI analysis with reduced computational time.

关键词： soil structure interaction     optimum lateral extent of soil domain length     multi-storyed framed building     pile foundation     OpenSEES     L-K boundaries     dynamic analysis    

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标题 作者 时间 类型 操作

Talin and kindlin: the one-two punch in integrin activation

null

期刊论文

Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

期刊论文

Transmembrane transport of polycyclic aromatic hydrocarbons by bacteria and functional regulation of

Hongqi Wang, Ruhan Jiang, Dekang Kong, Zili Liu, Xiaoxiong Wu, Jie Xu, Yi Li

期刊论文

Entity and relation extraction with rule-guided dictionary as domain knowledge

期刊论文

Damage identification in connections of moment frames using time domain responses and an optimization

期刊论文

Controlling microbiological interfacial behaviors of hydrophobic organic compounds by surfactants in biodegradation process

ZHANG Dong,ZHU Lizhong

期刊论文

Terahertz time-domain spectroscopy of high-pressure flames

Jason BASSI, Mark STRINGER, Bob MILES, Yang ZHANG

期刊论文

framework for underground structures in layered ground under inclined P-SV waves using stiffness matrix and domain

期刊论文

无监督域自适应的动态参数化学习

蒋润华1,2,韩亚洪1,2

期刊论文

针对无监督域自适应问题的深度逐层领域修正算法

Shuang LI, Shi-ji SONG, Cheng WU

期刊论文

Frequency domain a9ctive vibration control of a flexible plate based on neural networks

Jinxin LIU, Xuefeng CHEN, Zhengjia HE

期刊论文

Thermal reffusivity: uncovering phonon behavior, structural defects, and domain size

Yangsu XIE, Bowen ZHU, Jing LIU, Zaoli XU, Xinwei WANG

期刊论文

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

期刊论文

Analytical method of capsizing probability in the time domain for ships in the random beam seas

LIU Liqin, TANG Yougang, LI Hongxia

期刊论文

Optimum lateral extent of soil domain for dynamic SSI analysis of RC framed buildings on pile foundations

Nishant SHARMA, Kaustubh DASGUPTA, Arindam DEY

期刊论文